Track 06 of 9
Drug Delivery Systems
Nanocarriers, controlled release, targeted therapeutics.
Drug delivery is the linchpin of modern therapeutics, with lipid nanoparticles (Acuitas, Genevant, Moderna SM-102) carrying mRNA and CRISPR payloads, and antibody-drug conjugates (Enhertu, Trodelvy, datopotamab deruxtecan) delivering cytotoxic warheads with unprecedented therapeutic indices. The track will examine extra-hepatic LNP targeting (SORT particles, GalNAc-conjugated systems for non-liver tissue), engineered exosomes (Codiak, Evox), polymer micelles, and stimuli-responsive depots. Oral biologics, intranasal CNS delivery, and ultrasound-mediated blood-brain barrier opening (Insightec) will be examined alongside the regulatory and CMC challenges of next-generation modalities.
Focus areas
- Lipid nanoparticles for mRNA and gene editing payloads
- Antibody-drug conjugates: linker chemistry and bystander effects
- Extra-hepatic targeting: SORT LNPs, GalNAc, peptide-conjugates
- Engineered exosomes: Codiak, Evox therapeutic platforms
- Focused-ultrasound BBB opening for CNS drug delivery
- Oral biologics and intestinal permeation enhancers
- Stimuli-responsive hydrogels and long-acting injectables